Igor (voiced by John Cusack) is a brilliant young scientist sidelined by a physical deformity. Despite his position as a lowly assistant to mad Dr. Glickenstein (John Cleese), Igor dreams of winning the Evil Science Fair and the heart of Gretchen, a village beauty. Aided by a zombie rabbit (Steve Buscemi) and a brain in a jar (Sean Hayes), Igor might just hit the big time. Molly Shannon and Jennifer Coolidge also lend their vocal talent.