Ned (Paul Rudd) is a seemingly clueless idealist who must rely upon his three exasperated sisters (Emily Mortimer, Elizabeth Banks and Zooey Deschanel) for shelter and support after he's dumped by his fed-up girlfriend (Kathryn Hahn) and loses custody of his beloved dog, Willie Nelson. As he wreaks havoc on his sisters' lives, Ned's earnestness shines through until his siblings realize that family ties take priority over wealth and position.