Intense professional rivalry prolongs the instinctive antipathy between the impeccably dressed BHPD Lieutenant Ray Tango and his impulsive polar opposite, LAPD Lieutenant Gabe Cash. And as they get in each other's way, Yves Perret, a ruthless international drug lord, plans his next move. But instead of bringing down their arch-nemesis, falsified evidence condemns the crime fighters to rot in a maximum-security prison. As their former enemies, hardened criminals incarcerated by them, ache to get their sweet revenge on their captors, Tango and Cash must put their differences aside to survive imprisonment and clear their names. But good plans are hard to come by. Can the mismatched partners learn how to work together and get even with the brutal crime baron?