John Forbes Nash Jr. (Russell Crowe) was a brilliant economist -- when his mind was clear. But life changed forever with the revelation that he was a schizophrenic. Nash's brilliance persisted amidst the anguish his mental illness caused for him and his wife (Jennifer Connolly), and 40 years after his diagnosis, he won the Nobel Prize for economics. Connolly's acting and Ron Howard's direction won Oscars, and the film was named Best Picture.