In 1986, federal agent Robert Mazur (Bryan Cranston) goes under cover to infiltrate the trafficking network of Colombian drug kingpin Pablo Escobar. Working with fellow agents Kathy Ertz (Diane Kruger) and Emir Abreu (John Leguizamo), Mazur poses as a slick, money-laundering businessman named Bob Musella. Gaining the confidence of Roberto Alcaino (Benjamin Bratt), Escobar's top lieutenant, Mazur must navigate a vicious criminal underworld where one wrong move could cost him everything.