J.B. Books (John Wayne, in his final film role) is an aging gunfighter diagnosed with cancer who comes to Nevada at the turn of the 20th century. Renting a room from widowed Bond Rogers (Lauren Bacall) and her son Gillom (Ron Howard), Books is confronted by several people of questionable motives, including a man seeking to avenge his brother's death and a few who are looking to profit from Books' notoriety. Not wanting to die a quiet, painful death, Books devises a plan to go out with a bang.