The lives of various characters intersect at Harlem's renowned Cotton Club. Handsome horn player Dix Dwyer (Richard Gere) falls for Vera Cicero (Diane Lane), the stunning girlfriend of famous gangster Dutch Schultz (James Remar). Meanwhile Dix's brother, Vincent (Nicolas Cage), falls in with Schultz's crew, while Owney Madden (Bob Hoskins), the jazz venue's proprietor, has his own mob ties. Although Dix goes on to become a Hollywood actor, his life doesn't get any less complicated or dangerous.