When he was young, Howard Phillips (Jason Barry) watched his sister get torn apart by one of Dr. Herbert West's (Jeffrey Combs) reanimated corpses. Phillips, now a doctor, is so eager to learn more about the mad doctor's attempts to bring back the dead that he accepts a position at the prison where West is being held. Phillips delves further into West's gruesome research, which attracts the attention of a local reporter (Elsa Pataky) and the cruel prison warden (Simón Andreu).