Bud (Pauly Shore) and Doyle (Stephen Baldwin) get simultaneously dumped by their eco-conscious girlfriends, Monique (Joey Lauren Adams) and Jen (Teresa Hill), in the middle of the desert. Needing a bathroom, the two friends enter what they think is a mall but soon realize is a high-profile, secure biological experiment. As they engage in a year-long battle with Dr. Faulkner (William Atherton) and the other scientists, Bud and Doyle are forced to confront the recklessness of their behavior.